Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels
Name
PhysRevLett.124.048102.pdf
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1.09 MB
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Author(s)
Paraschiv, Alexandru
Hegde, Smitha
Ganti, Raman
Pilizota, Teuta
Šarić, Anđela
Date Issued
January 2020
Journal
Physical Review Letters
Publisher
American Physical Society (APS)
Citation
Paraschiv, Alexandru, et al. "Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels." Physical Review of Letters, 124, 4 (January 2020): 048102. © 2020 American Physical Society
Version
Final published version
Abstract
Experiments have suggested that bacterial mechanosensitive channels separate into 2D clusters, the role of which is unclear. By developing a coarse-grained computer model we find that clustering promotes the channel closure, which is highly dependent on the channel concentration and membrane stress. This behaviour yields a tightly regulated gating system, whereby at high tensions channels gate individually, and at lower tensions the channels spontaneously aggregate and inactivate. We implement this positive feedback into the model for cell volume regulation, and find that the channel clustering protects the cell against excessive loss of cytoplasmic content.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
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DOI of Published Version
https://doi.org/10.1103/PhysRevLett.124.048102
