Understanding the tumor immune microenvironment (TIME) for effective therapy
Name
Weinberg_Understanding the tumor.pdf
Size
677.59 KB
Format
Adobe PDF
Checksum (MD5)
4da80aa9f65a8be51d9d1658998e30d8
Author(s)
Binnewies, Mikhail
Roberts, Edward W.
Kersten, Kelly
Chan, Vincent
Fearon, Douglas F.
Merad, Miriam
Coussens, Lisa M.
Gabrilovich, Dmitry I.
Ostrand-Rosenberg, Suzanne
Hedrick, Catherine C.
Date Issued
April 2018
Journal
Nature Medicine
Publisher
Nature Publishing Group
Citation
Binnewies, Mikhail et al. “Understanding the Tumor Immune Microenvironment (TIME) for Effective Therapy.” Nature Medicine 24, 5 (April 2018): 541–550 © 2018 Nature America Inc., part of Springer Nature
Version
Author's final manuscript
Abstract
The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have experienced minimal or no clinical benefit when provided the same treatment. As technology has advanced, so has the understanding of the complexity and diversity of the immune context of the tumor microenvironment and its influence on response to therapy. It has been possible to identify different subclasses of immune environment that have an influence on tumor initiation and response and therapy; by parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient's tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/S41591-018-0014-X
