Wearable bioadhesive ultrasound shear wave elastography
Name
sciadv.adk8426.pdf
Description
Published version
Size
8.43 MB
Format
Adobe PDF
Checksum (MD5)
94fa3dbe7d27d3658acf24e79ea1224c
Author(s)
Liu, Hsiao-Chuan
Zeng, Yushun
Gong, Chen
Chen, Xiaoyu
Kijanka, Piotr
Zhang, Junhang
Genyk, Yuri
Tchelepi, Hisham
Wang, Chonghe
Zhou, Qifa
Date Issued
February 9, 2024
Journal
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Liu, Hsiao-Chuan, Zeng, Yushun, Gong, Chen, Chen, Xiaoyu, Kijanka, Piotr et al. 2024. "Wearable bioadhesive ultrasound shear wave elastography." Science Advances, 10 (6).
Version
Final published version
Abstract
Acute liver failure (ALF) is a critical medical condition defined as the rapid development of hepatic dysfunction. Conventional ultrasound elastography cannot continuously monitor liver stiffness over the course of rapidly changing diseases for early detection due to the requirement of a handheld probe. In this study, we introduce wearable bioadhesive ultrasound elastography (BAUS-E), which can generate acoustic radiation force impulse (ARFI) to induce shear waves for the continuous monitoring of modulus changes. BAUS-E contains 128 channels with a compact design with only 24 mm in the azimuth direction for comfortable wearability. We further used BAUS-E to continuously monitor the stiffness of in vivo rat livers with ALF induced by
d -galactosamine over 48 hours, and the stiffness change was observed within the first 6 hours. BAUS-E holds promise for clinical applications, particularly in patients after organ transplantation or postoperative care in the intensive care unit (ICU).
d -galactosamine over 48 hours, and the stiffness change was observed within the first 6 hours. BAUS-E holds promise for clinical applications, particularly in patients after organ transplantation or postoperative care in the intensive care unit (ICU).
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/sciadv.adk8426
