Animal-to-Animal Variability in Partial Hippocampal Remapping in Repeated Environments
Name
5268.full.pdf
Description
Published version
Size
2.97 MB
Format
Adobe PDF
Checksum (MD5)
ee75b8bb2cd1e29841a6e970b4c9afe7
Author(s)
Nilchian, Parsa
Wilson, Matthew A
Sanders, Honi
Date Issued
2022
Journal
Journal of Neuroscience
Publisher
Society for Neuroscience
Citation
Nilchian, Parsa, Wilson, Matthew A and Sanders, Honi. 2022. "Animal-to-Animal Variability in Partial Hippocampal Remapping in Repeated Environments." Journal of Neuroscience, 42 (26).
Version
Final published version
Abstract
Hippocampal place cells form a map of the environment of an animal. Changes in the hippocampal map can be brought about in a number of ways, including changes to the environment, task, internal state of the subject, and the passage of time. These changes in the hippocampal map have been called remapping. In this study, we examine remapping during repeated exposure to the same environment. Different animals can have different remapping responses to the same changes. This variability across animals in remapping behavior is not well understood. In this work, we analyzed electrophysiological recordings from the CA3 region of the hippocampus performed by Alme et al. (2014), in which five male rats were exposed to 11 different environments, including a variety of repetitions of those environments. To compare the hippocampal maps between two experiences, we computed average rate map correlation coefficients. We found changes in the hippocampal maps between different sessions in the same environment. These changes consisted of partial remapping, a form of remapping in which some place cells maintain their place fields, whereas other place cells remap their place fields. Each animal exhibited partial remapping differently. We discovered that the heterogeneity in hippocampal representational changes across animals is structured; individual animals had consistently different levels of partial remapping across a range of independent comparisons. Our findings highlight that partial hippocampal remapping between repeated environments depends on animal-specific factors.SIGNIFICANCE STATEMENT Context identification is a difficult problem. Animals are not provided with objective context identity labels, so they must infer which experiences come from which contexts. Different animals may have different strategies for performing this inference. We find that different animals have stereotypically different extents of partial hippocampal remapping, a neural correlate of subjective assessment of context identity.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1523/JNEUROSCI.3221-20.2022
