Integrating Machine Learning and Large Language Models to Advance Exploration of Electrochemical Reactions
Name
Angew Chem Int Ed - 2024 - Zheng - Integrating Machine Learning and Large Language Models to Advance Exploration of.pdf
Description
Published version
Size
5.33 MB
Format
Adobe PDF
Checksum (MD5)
6ac325b94c18d68d93d72d25cf3bf900
Author(s)
Zheng, Zhiling
Florit, Federico
Jin, Brooke
Wu, Haoyang
Li, Shih‐Cheng
Nandiwale, Kakasaheb Y
Salazar, Chase A
Mustakis, Jason G
Green, William H
Jensen, Klavs F
Date Issued
December 3, 2024
Journal
Angewandte Chemie International Edition
Publisher
Wiley
Citation
Zheng, Zhiling, Florit, Federico, Jin, Brooke, Wu, Haoyang, Li, Shih‐Cheng et al. 2024. "Integrating Machine Learning and Large Language Models to Advance Exploration of Electrochemical Reactions." Angewandte Chemie International Edition, 64 (6).
Version
Final published version
Abstract
Electrochemical C−H oxidation reactions offer a sustainable route to functionalize hydrocarbons, yet identifying suitable substrates and optimizing synthesis remain challenging. Here, we report an integrated approach combining machine learning and large language models to streamline the exploration of electrochemical C−H oxidation reactions. Utilizing a batch rapid screening electrochemical platform, we evaluated a wide range of reactions, initially classifying substrates by their reactivity, while LLMs text‐mined literature data to augment the training set. The resulting ML models for reactivity prediction achieved high accuracy (>90 %) and enabled virtual screening of a large set of commercially available molecules. To optimize reaction conditions for selected substrates, LLMs were prompted to generate code that iteratively improved yields. This human‐AI collaboration proved effective, efficiently identifying high‐yield conditions for 8 drug‐like substances or intermediates. Notably, we benchmarked the accuracy and reliability of 12 different LLMs–including LLaMA series, Claude series, OpenAI o1, and GPT‐4‐on code generation and function calling related to ML based on natural language prompts given by chemists to showcase potentials for accelerating research across four diverse tasks. In addition, we collected an experimental benchmark dataset comprising 1071 reaction conditions and yields for electrochemical C−H oxidation reactions.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/anie.202418074
