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Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube: A Primer with Latest Insights
Name
bies.201900186.pdf
Description
Published version
Size
2.84 MB
Format
Adobe PDF
Checksum (MD5)
228f98fc77c619e5723d39a99639757d
Author(s)
Fame, Ryann M
Cortés-Campos, Christian
Sive, Hazel L
Date Issued
2020
Journal
BioEssays
Publisher
Wiley
Citation
Fame, Ryann M, Cortés-Campos, Christian and Sive, Hazel L. 2020. "Brain Ventricular System and Cerebrospinal Fluid Development and Function: Light at the End of the Tube: A Primer with Latest Insights." BioEssays, 42 (3).
Version
Final published version
Abstract
© 2020 WILEY Periodicals, Inc. The brain ventricular system is a series of connected cavities, filled with cerebrospinal fluid (CSF), that forms within the vertebrate central nervous system (CNS). The hollow neural tube is a hallmark of the chordate CNS, and a closed neural tube is essential for normal development. Development and function of the ventricular system is examined, emphasizing three interdigitating components that form a functional system: ventricle walls, CSF fluid properties, and activity of CSF constituent factors. The cellular lining of the ventricle both can produce and is responsive to CSF. Fluid properties and conserved CSF components contribute to normal CNS development. Anomalies of the CSF/ventricular system serve as diagnostics and may cause CNS disorders, further highlighting their importance. This review focuses on the evolution and development of the brain ventricular system, associated function, and connected pathologies. It is geared as an introduction for scholars with little background in the field.
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1002/BIES.201900186
