Growth and division—not a one-way road
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nihms219858.pdf
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Author(s)
Goranov, Alexi I.
Amon, Angelika B.
Date Issued
July 2010
Journal
Current Opinion in Cell Biology
Publisher
Elsevier
Citation
Goranov, Alexi I and Angelika Amon. “Growth and Division—not a One-Way Road.” Current Opinion in Cell Biology 22, 6 (December 2010): 795–800 © 2010 Elsevier Ltd
Version
Author's final manuscript
Abstract
Maintaining cell size homeostasis and regulating cell size in response to changing conditions is a fundamental property of organisms. Here we examine the recent advances in our understanding of the interplay between accumulation of mass (growth) and the progression through the cell cycle (proliferation), the coordination of which determines the size of cells. It is well established that growth affects cell division (reviewed in Jorgensen and Tyers, 2004 [1]). This review will focus on the reverse, less well-defined relationship-how cell cycle progression affects growth. We will summarize findings that indicate that growth is not constant during the cell cycle and discuss the surprising possibility that cyclin-dependent kinases (CDKs) inhibit growth.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1016/j.ceb.2010.06.004
