Microbiome therapeutics — Advances and challenges
Name
nihms825214.pdf
Description
Accepted version
Size
773.09 KB
Format
Adobe PDF
Checksum (MD5)
c7d0258ceaa5a7d59ebf6d2d3ef68621
Author(s)
Mimee, Mark
Citorik, Robert J
Lu, Timothy K
Date Issued
2016
Journal
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Citation
Mimee, M., R. J. Citorik, and T. K. Lu. "Microbiome Therapeutics - Advances and Challenges." Adv Drug Deliv Rev (2016).
Version
Author's final manuscript
Abstract
© 2016 The microbial community that lives on and in the human body exerts a major impact on human health, from metabolism to immunity. In order to leverage the close associations between microbes and their host, development of therapeutics targeting the microbiota has surged in recent years. Here, we discuss current additive and subtractive strategies to manipulate the microbiota, focusing on bacteria engineered to produce therapeutic payloads, consortia of natural organisms and selective antimicrobials. Further, we present challenges faced by the community in the development of microbiome therapeutics, including designing microbial therapies that are adapted for specific geographies in the body, stable colonization with microbial therapies, discovery of clinically relevant biosensors, robustness of engineered synthetic gene circuits and addressing safety and biocontainment concerns. Moving forward, collaboration between basic and applied researchers and clinicians to address these challenges will poise the field to herald an age of next-generation, cellular therapies that draw on novel findings in basic research to inform directed augmentation of the human microbiota.
MIT Department
Massachusetts Institute of Technology. Microbiology Graduate Program
Massachusetts Institute of Technology. Synthetic Biology Center
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.ADDR.2016.04.032
