Enhanced Reaction Efficiency in Continuous Flow
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Enhanced Reaction Efficiency in Continuous Flow.pdf
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706.57 KB
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Adobe PDF
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Author(s)
Morse, Peter D
Beingessner, Rachel L
Jamison, Timothy F
Date Issued
April 2017
Journal
Israel Journal of Chemistry
Publisher
Wiley Blackwell
Citation
Morse, Peter D. et al. “Enhanced Reaction Efficiency in Continuous Flow.” Israel Journal of Chemistry 57, 3–4 (November 2016): 218–227 © 2017 Wiley‐VCH Verlag GmbH & Co
Version
Author's final manuscript
Abstract
Continuous flow reactors are enabling tools that can significantly benefit chemical reactions, especially those that are path length dependent (e.g., photochemical), mixing or transport dependent (e.g., gas‐liquid), exothermic, or utilize hazardous or unstable intermediates. In this review, it is demonstrated how the nearly instantaneous mixing, exceptionally fast mass transfer, safe access to high temperatures and pressures, and high surface area to volume ratio can be leveraged to improve product yield, reaction rates and/or selectivity. By showcasing five synthetic methodologies examined by our group, it is hoped that the reader will gain an appreciation of the accessible and transformative nature of flow chemistry for improving existing transformations, enabling rapid optimization, and for developing new methodologies that depend on precise parameter controls. Keywords: flow chemistry; process intensification; microreactors; photochemistry; synthesis design
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/ijch.201600095
