Induction and molecular signature of pathogenic T[subscript H]17 cells
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Regev_Induction and molecular.pdf
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Author(s)
Lee, Youjin
Awasthi, Amit
Yosef, Nir
Quintana, Francisco J.
Xiao, Sheng
Peters, Anneli
Wu, Chuan
Kleinewietfeld, Markus
Kunder, Sharon
Hafler, David A.
Date Issued
September 2012
Journal
Nature Immunology
Publisher
Nature Publishing Group
Citation
Lee, Youjin, Amit Awasthi, Nir Yosef, Francisco J Quintana, Sheng Xiao, Anneli Peters, Chuan Wu, et al. “Induction and molecular signature of pathogenic TH17 cells.” Nature Immunology 13, no. 10 (September 9, 2012): 991-999.
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Author's final manuscript
Abstract
Interleukin 17 (IL-17)-producing helper T cells (T[subscript H]17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T[subscript H]17 cells are main drivers of autoimmune tissue injury. However, not all T[subscript H]17 cells are pathogenic; in fact, T[subscript H]17 cells generated with transforming growth factor-β1 (TGF-β1) and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we found that the production of TGF-β3 by developing T[subscript H]17 cells was dependent on IL-23, which together with IL-6 induced very pathogenic T[subscript H]17 cells. Moreover, TGF-β3-induced T[subscript H]17 cells were functionally and molecularly distinct from TGF-β1-induced T[subscript H]17 cells and had a molecular signature that defined pathogenic effector T[subscript H]17 cells in autoimmune disease.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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DOI of Published Version
https://doi.org/10.1038/ni.2416
