Remotely Controlled Proton Generation for Neuromodulation
Name
nihms-1749965.pdf
Description
Accepted version
Size
1.49 MB
Format
Adobe PDF
Checksum (MD5)
7164b21c43f400ddb4ffa3d44ff3474c
Author(s)
Park, Jimin
Tabet, Anthony
Moon, Junsang
Chiang, Po-Han
Koehler, Florian
Sahasrabudhe, Atharva
Anikeeva, Polina
Date Issued
2020
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Park, Jimin, Tabet, Anthony, Moon, Junsang, Chiang, Po-Han, Koehler, Florian et al. 2020. "Remotely Controlled Proton Generation for Neuromodulation." Nano Letters, 20 (9).
Version
Author's final manuscript
Abstract
Copyright © 2020 American Chemical Society. Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting noninvasive alternating magnetic fields (AMFs) into protons in physiological environments by combining magnetic nanoparticles (MNPs) with polymeric scaffolds. When exposed to AMFs, the heat dissipated by MNPs triggered a hydrolytic degradation of surrounding polyanhydride or polyester, releasing protons into the extracellular space. pH changes induced by these nanotransducers can be tuned by changing the polymer chemistry or AMF stimulation parameters. Remote magnetic control of local protons was shown to trigger acid-sensing ion channels and to evoke intracellular calcium influx in neurons. By offering a wireless modulation of local pH, our approach can accelerate the mechanistic investigation of the role of protons in biochemical signaling in the nervous system.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Research Laboratory of Electronics
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Attribution-NonCommercial-ShareAlike 4.0 International
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DOI of Published Version
https://doi.org/10.1021/ACS.NANOLETT.0C02281
