B Cells Promote Pancreatic Tumorigenesis
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ChenCancerdisco.pdf
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Author(s)
Roghanian, Ali
Fraser, Christopher
Kleyman, Marianna
Chen, Jianzhu
Date Issued
March 2016
Journal
Cancer Discovery
Publisher
American Association for Cancer Research (AACR)
Citation
Roghanian, Ali, Christopher Fraser, Marianna Kleyman, and Jianzhu Chen. “B Cells Promote Pancreatic Tumorigenesis.” Cancer Discovery 6, no. 3 (March 1, 2016): 230-232.
Version
Author's final manuscript
Abstract
Summary: Three recent studies, approaching the question from different angles and using different and/or overlapping models, provide compelling evidence for the involvement of tumor-infiltrating B cells in the initiation and progression of pancreatic ductal adenocarcinoma. These studies highlight the need for a better understanding of pancreatic tumor–immune system interactions and the immunologic mechanisms that promote or inhibit tumorigenesis, paving the way for better treatment strategies.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1158/2159-8290.cd-16-0100
