Developmental Dynamics of Rett Syndrome
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Author(s)
Banerjee, Abhishek
Sur, Mriganka
Feldman, Danielle Angela
Date Issued
2016
Journal
Neural Plasticity
Publisher
Hindawi Publishing Corporation
Citation
Feldman, Danielle, Abhishek Banerjee, and Mriganka Sur. “Developmental Dynamics of Rett Syndrome.” Neural Plasticity 2016 (2016): 1–9.
Version
Final published version
Abstract
Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood. A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, including developmental stages that define neurogenesis, migration, and patterning in addition to stages of synaptic and circuit development and plasticity. These phenotypes arise from the pleotropic effects of MeCP2, which is expressed very early in neuronal progenitors and continues to be expressed into adulthood. The effects of MeCP2 are mediated by diverse signaling, transcriptional, and epigenetic mechanisms. Attempts to reverse the effects of Rett Syndrome need to take into account the developmental dynamics and temporal impact of MeCP2 loss.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1155/2016/6154080
