Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers
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Manuscript - Fei Tian.pdf
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1.99 MB
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Author(s)
Tian, Fei
Min, Jouha
Kanka, Jiri
Li, Xiangzhi
Du, Henry
Hammond, Paula T
Date Issued
July 2015
Journal
Optics Express
Publisher
Optical Society of America
Citation
Tian, Fei, Jouha Min, Jiri Kanka, Xiangzhi Li, Paula T. Hammond, and Henry Du. “Lab-on-Fiber Optofluidic Platform for in Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers.” Optics Express 23, no. 15 (July 24, 2015): 20132.
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Author's final manuscript
Abstract
A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1364/oe.23.020132
