Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
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s41563-024-01811-5.pdf
Description
Published version
Size
1.48 MB
Format
Adobe PDF
Checksum (MD5)
bdc015913799bc7ee302a46b411a1d65
Author(s)
Liu, Gary W
Pickett, Matthew J
Kuosmanen, Johannes LP
Ishida, Keiko
Madani, Wiam AM
White, Georgia N
Jenkins, Joshua
Park, Sanghyun
Feig, Vivian R
Jimenez, Miguel
Date Issued
February 27, 2024
Journal
Nature Materials
Publisher
Springer Science and Business Media LLC
Citation
Liu, G.W., Pickett, M.J., Kuosmanen, J.L.P. et al. Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics. Nat. Mater. 23, 1292–1299 (2024).
Version
Final published version
Abstract
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe drug formulations based on liquid in situ-forming tough (LIFT) hydrogels that bridge the advantages of solid and liquid dosage forms. LIFT hydrogels form directly in the stomach through sequential ingestion of a crosslinker solution of calcium and dithiol crosslinkers, followed by a drug-containing polymer solution of alginate and four-arm poly(ethylene glycol)-maleimide. We show that LIFT hydrogels robustly form in the stomachs of live rats and pigs, and are mechanically tough, biocompatible and safely cleared after 24 h. LIFT hydrogels deliver a total drug dose comparable to unencapsulated drug in a controlled manner, and protect encapsulated therapeutic enzymes and bacteria from gastric acid-mediated deactivation. Overall, LIFT hydrogels may expand access to advanced therapeutics for patients with difficulty swallowing.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Media Laboratory
Broad Institute of MIT and Harvard
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DOI of Published Version
https://doi.org/10.1038/s41563-024-01811-5
