Magnetic Living Hydrogels for Intestinal Localization, Retention, and Diagnosis
Name
10.1002-adfm.202010918.pdf
Size
2.39 MB
Format
Unknown
Checksum (MD5)
b1cfe3e9aa9241fda67357dbf578b356
Author(s)
Liu, Xinyue
Yang, Yueying
Inda, Maria Eugenia
Lin, Shaoting
Wu, Jingjing
Kim, Yoonho
Chen, Xiaoyu
Ma, Dacheng
Lu, Timothy K.
Zhao, Xuanhe
Date Issued
April 2021
Journal
Advanced Functional Materials
Publisher
Wiley
Citation
Liu, Xinyue, Yang, Yueying, Inda, Maria Eugenia, Lin, Shaoting, Wu, Jingjing et al. 2021. "Magnetic Living Hydrogels for Intestinal Localization, Retention, and Diagnosis." Advanced Functional Materials, 31 (27).
Version
Author's final manuscript
Abstract
Natural microbial sensing circuits can be rewired into new gene networks to build living sensors that detect and respond to disease-associated biomolecules. However, synthetic living sensors, once ingested, are cleared from the gastrointestinal (GI) tract within 48 h; retaining devices in the intestinal lumen is prone to intestinal blockage or device migration. To localize synthetic microbes and safely extend their residence in the GI tract for health monitoring and sustained drug release, an ingestible magnetic hydrogel carrier is developed to transport diagnostic microbes to specific intestinal sites. The magnetic living hydrogel is localized and retained by attaching a magnet to the abdominal skin, resisting the peristaltic waves in the intestine. The device retention is validated in a human intestinal phantom and an in vivo rodent model, showing that the ingestible hydrogel maintains the integrated living bacteria for up to seven days, which allows the detection of heme for GI bleeding in the harsh environment of the gut. The retention of microelectronics is also demonstrated by incorporating a temperature sensor into the magnetic hydrogel carrier.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Massachusetts Institute of Technology. Research Laboratory of Electronics
Massachusetts Institute of Technology. Synthetic Biology Center
Massachusetts Institute of Technology. Center for Biomedical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adfm.202010918
