mTOR at the nexus of nutrition, growth, ageing and disease
Name
nihms-1559311.pdf
Description
Accepted version
Size
2.87 MB
Format
Adobe PDF
Checksum (MD5)
8f90c6b860221426e6a8c8022574fb31
Author(s)
Liu, Grace Y
Sabatini, David M
Date Issued
2020
Journal
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Version
Author's final manuscript
Abstract
© 2020, Springer Nature Limited. The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway’s central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing. In this Review, we highlight recent advances in our understanding of the complex regulation of the mTOR pathway and discuss its function in the context of physiology, human disease and pharmacological intervention.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Howard Hughes Medical Institute
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/S41580-019-0199-Y
