An ingestible bacterial-electronic system to monitor gastrointestinal health
Name
nihms-1018292.pdf
Description
Accepted version
Size
785.86 KB
Format
Adobe PDF
Checksum (MD5)
88c8a203303aee0798da576a908c55a9
Author(s)
Mimee, Mark Kyle
Nadeau, Phillip
Hayward, Alison M
Carim, Sean
Flanagan, Sarah
Jerger, Logan Andrew
Collins, Joy E
McDonnell, Shane
Swartwout, Richard M
Citorik, Robert James
Date Issued
May 2018
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Mimee, Mark et al. "An ingestible bacterial-electronic system to monitor gastrointestinal health." Science 360, 6391 (May 2018): 915-918 © 2017 The Authors
Version
Author's final manuscript
Abstract
Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease detection and management but is impeded by access to the remote and complex environment. Here, we present an ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device. As a proof of concept, we engineer heme-sensitive probiotic biosensors and demonstrate accurate diagnosis of gastrointestinal bleeding in swine. Additionally, we integrate alternative biosensors to demonstrate modularity and extensibility of the detection platform. IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease.
MIT Department
Massachusetts Institute of Technology. Synthetic Biology Center
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
http://dx.doi.org/10.1126/science.aas9315
