Biomaterial Strategies for Immunomodulation
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Irvine_Biomaterial strategies.pdf
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2.56 MB
Format
Adobe PDF
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Author(s)
Hotaling, Nathan A.
Babensee, Julia E.
Tang, Li
Irvine, Darrell J
Date Issued
December 2015
Journal
Annual Review of Biomedical Engineering
Publisher
Annual Reviews
Citation
Hotaling, Nathan A., Li Tang, Darrell J. Irvine, and Julia E. Babensee. “Biomaterial Strategies for Immunomodulation.” Annual Review of Biomedical Engineering 17, no. 1 (December 7, 2015): 317–349.
Version
Author's final manuscript
Abstract
Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for regenerative medicine, and immunotherapies for cancer. However, the intricate cellular and molecular signals regulating the immune system are major hurdles to predictably manipulating the immune response and developing safe and effective therapies. To meet this challenge, biomaterials are being developed that control how, where, and when immune cells are stimulated in vivo, and that can finely control their differentiation in vitro. We review recent advances in the field of biomaterials for immunomodulation, focusing particularly on designing biomaterials to provide controlled immunostimulation, targeting drugs and vaccines to lymphoid organs, and serving as scaffolds to organize immune cells and emulate lymphoid tissues. These ongoing efforts highlight the many ways in which biomaterials can be brought to bear to engineer the immune system.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1146/annurev-bioeng-071813-104814
