Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids
Name
Dedon_Biologically relevant.pdf
Size
789.95 KB
Format
Adobe PDF
Checksum (MD5)
ff969e0a7a674dfa03ca81bfea023ff3
Author(s)
Cadet, Jean
Loft, Steffen
Olinski, Ryszard
Evans, Mark D.
Bialkowski, Karol
Richard Wagner, J.
Dedon, Peter C.
Moller, Peter
Greenberg, Marc M.
Cooke, Marcus S.
Date Issued
April 2012
Journal
Free Radical Research
Publisher
Informa UK (Informa Healthcare)
Citation
Cadet, Jean, Steffen Loft, Ryszard Olinski, Mark D. Evans, Karol Bialkowski, J. Richard Wagner, Peter C. Dedon, Peter Moller, Marc M. Greenberg, and Marcus S. Cooke. “Biologically Relevant Oxidants and Terminology, Classification and Nomenclature of Oxidatively Generated Damage to Nucleobases and 2-Deoxyribose in Nucleic Acids.” Free Radic Res 46, no. 4 (April 2012): 367–381.
Version
Author's final manuscript
Abstract
A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3109/10715762.2012.659248
