Striatal origin of the pathologic beta oscillations in Parkinson's disease
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Boyden-2011-June-Striatal origin of the pathologic.pdf
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Author(s)
McCarthy, M. M.
Moore-Kochlacs, Caroline
Gu, X.
Han, X.
Kopell, Nancy J.
Boyden, Edward
Date Issued
June 2011
Journal
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences (PNAS)
Citation
McCarthy, M. M. et al. “Striatal Origin of the Pathologic Beta Oscillations in Parkinson’s Disease.” Proceedings of the National Academy of Sciences 108.28 (2011): 11620-11625. Web. 8 Feb. 2012. © 2011 American Physical Society
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Final published version
Abstract
Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations remain elusive. Here, using mathematical models, we find that robust beta oscillations can emerge from inhibitory interactions between striatal medium spiny neurons. The interaction of the synaptic GABAa currents and the intrinsic membrane M-current promotes population oscillations in the beta frequency range. Increased levels of cholinergic drive, a condition relevant to the parkinsonian striatum, lead to enhanced beta oscillations in the striatal model. We show experimentally that direct infusion of the cholinergic agonist carbachol into the striatum, but not into the neighboring cortex, of the awake, normal rodent induces prominent beta frequency oscillations in the local field potential. These results provide evidence for amplification of normal striatal network dynamics as a mechanism responsible for the enhanced beta frequency oscillations in Parkinson's disease.
Description
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.
1073/pnas.1107748108/-/DCSupplemental.
MIT Department
Massachusetts Institute of Technology. Media Laboratory
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1107748108
