Dissecting the antibody-OME: past, present, and future
Name
1-s2.0-S0952791520300662-main.pdf
Description
Published version
Size
1.07 MB
Format
Unknown
Checksum (MD5)
679522eba74167c74bf980901c83ef13
Author(s)
Loos, Carolin
Lauffenburger, Douglas A
Alter, Galit
Date Issued
2020
Journal
Current Opinion in Immunology
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The Authors Humoral immunity is key to protection for nearly all licensed vaccines. Yet, the design of vaccines has been more difficult for some of our most deadly killers (e.g. HIV, influenza, Dengue virus, etc.), likely due to our incomplete understanding of the precise immunological mechanisms associated with protection. Humoral immunity is governed both by B-cells and their bi-functional secreted antibodies, all of which have a unique capacity to evolve during an immune response. Current OMIC technologies capture individual features of the humoral immune response, providing a glimpse into humoral components (Fab/Fc/B-cell-omic), but fail to provide a wholistic view of the humoral response as a collective functional arm. Here, we dissect current OMIC strategies reviewing experimental and computational approaches, that if integrated could provide a true systems-level view of the humoral immune response.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Ragon Institute of MGH, MIT and Harvard
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.COI.2020.06.003
