On-patient medical record and mRNA therapeutics using intradermal microneedles
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s41563-024-02115-4.pdf
Description
Published version
Size
14.72 MB
Format
Adobe PDF
Checksum (MD5)
d2ff4a98192f9313dbb4a173f4674426
Author(s)
Han, Jooli
Kanelli, Maria
Liu, Yang
Daristotle, John L
Pardeshi, Apurva
Forster, Timothy A
Karchin, Ari
Folk, Brandon
Murmann, Lukas
Tostanoski, Lisa H
Date Issued
February 24, 2025
Journal
Nature Materials
Publisher
Springer Science and Business Media LLC
Citation
Han, J., Kanelli, M., Liu, Y. et al. On-patient medical record and mRNA therapeutics using intradermal microneedles. Nat. Mater. 24, 794–803 (2025).
Abstract
Medical interventions often require timed series of doses, thus necessitating accurate medical record-keeping. In many global settings, these records are unreliable or unavailable at the point of care, leading to less effective treatments or disease prevention. Here we present an invisible-to-the-naked-eye on-patient medical record-keeping technology that accurately stores medical information in the patient skin as part of microneedles that are used for intradermal therapeutics. We optimize the microneedle design for both a reliable delivery of messenger RNA (mRNA) therapeutics and the near-infrared fluorescent microparticles that encode the on-patient medical record-keeping. Deep learning-based image processing enables encoding and decoding of the information with excellent temporal and spatial robustness. Long-term studies in a swine model demonstrate the safety, efficacy and reliability of this approach for the co-delivery of on-patient medical record-keeping and the mRNA vaccine encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This technology could help healthcare workers make informed decisions in circumstances where reliable record-keeping is unavailable, thus contributing to global healthcare equity.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
Ragon Institute of MGH, MIT and Harvard
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1038/s41563-024-02115-4
