Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria
Name
nihms807385.pdf
Description
Accepted version
Size
2.14 MB
Format
Unknown
Checksum (MD5)
e7ddd3789a0972cbcc75bcb65fbe1a97
Author(s)
Chen, Xuan
Wu, Bin
Jayawardana, Kalana W.
Hao, Nanjing
Jayawardena, H. Surangi N.
Langer, Robert
Jaklenec, Ana
Yan, Mingdi
Date Issued
June 2016
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Chen, X., et al. "Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria." Adv Healthc Mater (2016).
Version
Author's final manuscript
Abstract
A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adhm.201600071
