Pyramidal neurons in the superficial layers of rat retrosplenial cortex exhibit a late-spiking firing property
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Kurotani_2012-Pyramidal neurons in.pdf
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Author(s)
Kurotani, Tohru
Miyashita, Toshio
Wintzer, Marie
Konishi, Tomokazu
Sakai, Kazuhisa
Ichinohe, Noritaka
Rockland, Kathleen
Date Issued
March 2012
Journal
Brain Structure and Function
Publisher
Springer-Verlag
Citation
Kurotani, Tohru, Toshio Miyashita, Marie Wintzer, Tomokazu Konishi, Kazuhisa Sakai, Noritaka Ichinohe, and Kathleen S. Rockland. “Pyramidal neurons in the superficial layers of rat retrosplenial cortex exhibit a late-spiking firing property.” Brain Structure and Function 218, no. 1 (January 1, 2013): 239-254.
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Final published version
Abstract
The rodent granular retrosplenial cortex (GRS) is reciprocally connected with the hippocampus. It is part of several networks implicated in spatial learning and memory, and is known to contain head-direction cells. There are, however, few specifics concerning the mechanisms and microcircuitry underlying its involvement in spatial and mnemonic functions. In this report, we set out to characterize intrinsic properties of a distinctive population of small pyramidal neurons in layer 2 of rat GRS. These neurons, as well as those in adjoining layer 3, were found to exhibit a late-spiking (LS) firing property. We established by multiple criteria that the LS property is a consequence of delayed rectifier and A-type potassium channels. These were identified as Kv1.1, Kv1.4 and Kv4.3 by Genechip analysis, in situ hybridization, single-cell reverse transcriptase-polymerase chain reaction, and pharmacological blockade. The LS property might facilitate comparison or integration of synaptic inputs during an interval delay, consistent with the proposed role of the GRS in memory-related processes.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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DOI of Published Version
https://doi.org/10.1007/s00429-012-0398-1
