Palladium-Catalyzed N-Arylation of 2-Aminothiazoles
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Buchwald_Palladium-catalyzed n-arylation.pdf
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Author(s)
McGowan, Meredeth A.
Henderson, Jaclyn L.
Buchwald, Stephen Leffler
Date Issued
March 2012
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
McGowan, Meredeth A., Jaclyn L. Henderson, and Stephen L. Buchwald. “Palladium-Catalyzed N-Arylation of 2-Aminothiazoles.” Organic Letters 14, no. 6 (March 16, 2012): 1432-1435.
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Author's final manuscript
Abstract
A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ol300178j
