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3D‐Printed Gastric Resident Electronics
Name
Kong_et_al-2019-Advanced_Materials_Technologies.pdf
Description
Published version
Size
2.61 MB
Format
Adobe PDF
Checksum (MD5)
126eed9d9fbd647d4fecfb09594af6e0
Author(s)
Kong, Yong Lin
Zou, Xingyu
McCandler, Caitlin A
Kirtane, Ameya R
Ning, Shen
Zhou, Jianlin
Abid, Abubakar
Jafari, Mousa
Rogner, Jaimie
Minahan, Daniel
Date Issued
2019
Journal
Advanced Materials Technologies
Publisher
Wiley
Version
Final published version
Abstract
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Long-term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long-term resident electronics devices require invasive procedures for implantation as well as a specialized receiver for communication. Here, a gastric resident electronic (GRE) system that leverages the anatomical space offered by the gastric environment to enable residence of an orally delivered platform of such devices within the human body is presented. The GRE is capable of directly interfacing with portable consumer personal electronics through Bluetooth, a widely adopted wireless protocol. In contrast to the passive day-long gastric residence achieved with prior ingestible electronics, advancement in multimaterial prototyping enables the GRE to reside in the hostile gastric environment for a maximum of 36 d and maintain ≈15 d of wireless electronics communications as evidenced by the studies in a porcine model. Indeed, the synergistic integration of reconfigurable gastric-residence structure, drug release modules, and wireless electronics could ultimately enable the next-generation remote diagnostic and automated therapeutic strategies.
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
10.1002/ADMT.201800490
