Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments
Name
Kamm_Microfluidic devices.pdf
Size
1.21 MB
Format
Adobe PDF
Checksum (MD5)
af8e78cdb860b14b13bb45d1ab5bb3d7
Author(s)
Zervantonakis, Ioannis K.
Kothapalli, Chandrasekhar R.
Chung, Seok
Sudo, Ryo
Kamm, Roger Dale
Date Issued
March 2011
Journal
Biomicrofluidics
Publisher
American Institute of Physics (AIP)
Citation
Zervantonakis, Ioannis K., Chandrasekhar R. Kothapalli, Seok Chung, Ryo Sudo, and Roger D. Kamm. “Microfluidic Devices for Studying Heterotypic Cell-Cell Interactions and Tissue Specimen Cultures Under Controlled Microenvironments.” Biomicrofluidics 5, no. 1 (2011): 013406. © 2011 American Institute of Physics
Version
Final published version
Abstract
Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitroassays, and allow real-time monitoring of homotypic or heterotypic cellularinteractions.Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and/or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1063/1.3553237
