Restoration of hippocampal growth hormone reverses stress-induced hippocampal impairment
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Vander Weele-2013-Restoration of hippo.pdf
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Author(s)
Vander Weele, Caitlin Miya
Saenz, Christopher
Yao, Junmei
dos Santos Correia, Susana Mar
Goosens, Ki Ann
Date Issued
June 2013
Journal
Frontiers in Behavioral Neuroscience
Publisher
Frontiers Research Foundation
Citation
Vander Weele, Caitlin M., Christopher Saenz, Junmei Yao, Susana S. Correia, and Ki A. Goosens. “Restoration of Hippocampal Growth Hormone Reverses Stress-Induced Hippocampal Impairment.” Front. Behav. Neurosci. 7 (2013).
Version
Final published version
Abstract
Though growth hormone (GH) is synthesized by hippocampal neurons, where its expression is influenced by stress exposure, its function is poorly characterized. Here, we show that a regimen of chronic stress that impairs hippocampal function in rats also leads to a profound decrease in hippocampal GH levels. Restoration of hippocampal GH in the dorsal hippocampus via viral-mediated gene transfer completely reversed stress-related impairment of two hippocampus-dependent behavioral tasks, auditory trace fear conditioning, and contextual fear conditioning, without affecting hippocampal function in unstressed control rats. GH overexpression reversed stress-induced decrements in both fear acquisition and long-term fear memory. These results suggest that loss of hippocampal GH contributes to hippocampal dysfunction following prolonged stress and demonstrate that restoring hippocampal GH levels following stress can promote stress resilience.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.3389/fnbeh.2013.00066
