Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep
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nihms878875.pdf
Description
Accepted version
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508.66 KB
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Author(s)
Akeju, Oluwaseun
Brown, Emery Neal
Date Issued
May 2017
Journal
Current Opinion in Neurobiology
Publisher
Elsevier BV
Citation
Akeju, Oluwaseun and Emery N Brown. "Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep." Current Opinion in Neurobiology, 44 (June 2017): 178-185 © 2017 Elsevier Ltd
Version
Author's final manuscript
Abstract
General anesthesia is a man-made neurophysiological state comprised of unconsciousness, amnesia, analgesia, and immobility along with maintenance of physiological stability. Growing evidence suggests that anesthetic-induced neural oscillations are a primary mechanism of anesthetic action. Each anesthetic drug class produces distinct oscillatory dynamics that can be related to the circuit mechanisms of drug action. Sleep is a naturally occurring state of decreased arousal that is essential for normal health. Physiological measurements (electrooculogram, electromyogram) and neural oscillatory (electroencephalogram) dynamics are used to empirically characterize sleep into rapid eye movement sleep and the three stages of non-rapid eye movement sleep. In this review, we discuss the differences between anesthesia- and sleep-induced altered states from the perspective of neural oscillations.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.conb.2017.04.011
