Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
Name
Chemistry A European J - 2022 - G rardy - Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives.pdf
Description
Published version
Size
1.03 MB
Format
Adobe PDF
Checksum (MD5)
afbbd5b4b14895a0bec830a4625ed61c
Author(s)
Gérardy, Romaric
Nambiar, Anirudh MK
Hart, Travis
Mahesh, Prajwal T
Jensen, Klavs F
Date Issued
August 2022
Journal
Chemistry – A European Journal
Publisher
Wiley
Citation
Gérardy, Romaric, Nambiar, Anirudh MK, Hart, Travis, Mahesh, Prajwal T and Jensen, Klavs F. 2022. "Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform." Chemistry – A European Journal, 28 (43).
Version
Final published version
Abstract
The implementation of self-optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self-optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C-C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/chem.202201385
