Rag proteins regulate amino-acid-induced mTORC1 signalling
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Sabatini_Rag proteins.pdf
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72.09 KB
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Checksum (MD5)
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Author(s)
Sancak, Yasemin
Sabatini, David
Date Issued
January 2009
Journal
Biochemical Society Transactions
Publisher
Biomedical Society
Citation
Sancak, Yasemin, and David M. Sabatini. “Rag Proteins Regulate Amino-acid-induced mTORC1 Signalling.” Biochemical Society Transactions 37.1 (2009) : 289-290.
Version
Final published version
Abstract
The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPase) family of GTPases as mediators of amino acid signalling to mTOR is an important step towards our understanding of this mechanism.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1042/bst0370289
