Nanoporous Elements in Microfluidics for Multiscale Manipulation of Bioparticles
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Wardle_Nanoporous elements.pdf
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Author(s)
Chen, Grace D.
Fachin, Fabio
Fernandez-Suarez, Marta
Wardle, Brian L.
Toner, Mehmet
Date Issued
March 2011
Journal
Small
Publisher
Wiley Blackwell
Citation
Chen, Grace D., Fabio Fachin, Marta Fernandez-Suarez, Brian L. Wardle, and Mehmet Toner. “Nanoporous Elements in Microfluidics for Multiscale Manipulation of Bioparticles.” Small 7, no. 8 (April 18, 2011): 1061-1067.
Version
Author's final manuscript
Abstract
Solid materials, such as silicon, glass, and polymers, dominate as structural elements in microsystems including microfluidics. Porous elements have been limited to membranes sandwiched between microchannel layers or polymer monoliths. This paper reports the use of micropatterned carbon-nanotube forests confined inside microfluidic channels for mechanically and/or chemically capturing particles ranging over three orders of magnitude in size. Nanoparticles below the internanotube spacing (80 nm) of the forest can penetrate inside the forest and interact with the large surface area created by individual nanotubes. For larger particles (>80 nm), the ultrahigh porosity of the nanotube elements reduces the fluid boundary layer and enhances particle–structure interactions on the outer surface of the patterned nanoporous elements. Specific biomolecular recognition is demonstrated using cells (≈10 μm), bacteria (≈1 μm), and viral-sized particles (≈40 nm) using both effects. This technology can provide unprecedented control of bioseparation processes to access bioparticles of interest, opening new pathways for both research and point-of-care diagnostics.
Description
Author Manuscript 2011 July 22
MIT Department
Massachusetts Institute of Technology. Department of Aeronautics and Astronautics
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
http://dx.doi.org/10.1002/smll.201002076
