Microfluidic jet injection for delivering macromolecules into cells
Name
Jensen_Microfluidic jet.pdf
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4.79 MB
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Author(s)
Roushdy, O.
Dokov, Rangel P.
Sharei, Armon Reza
Jensen, Klavs F.
Roushdy, O.
Adamo, Andrea, 1975-
Date Issued
February 2013
Journal
Journal of Micromechanics and Microengineering
Publisher
IOP Publishing
Citation
Adamo, A, O Roushdy, R Dokov, A Sharei, and K F Jensen. “Microfluidic Jet Injection for Delivering Macromolecules into Cells.” J. Micromech. Microeng. 23, no. 3 (February 6, 2013): 035026.
Version
Author's final manuscript
Abstract
We present a microfluidic-based injection system designed to achieve intracellular delivery of macromolecules by directing a picoliter jet of a solution toward the individual cells. After discussing the concept, we present design specification and criteria, elucidate performance and discuss results. The method has the potential to be quantitative and of high throughput, overcoming the limitations of current intracellular delivery protocols.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1088/0960-1317/23/3/035026
