Drug Delivery in Plants Using Silk Microneedles
Name
Advanced Materials - 2022 - Cao - Drug Delivery in Plants Using Silk Microneedles.pdf
Description
Published version
Size
7.28 MB
Format
Adobe PDF
Checksum (MD5)
3a444cef98367d7e67bf8d6ecbba005e
Author(s)
Cao, Yunteng
Koh, Sally Shuxian
Han, Yangyang
Tan, Javier Jingheng
Kim, Doyoon
Chua, Nam‐Hai
Urano, Daisuke
Marelli, Benedetto
Date Issued
January 2023
Journal
Advanced Materials
Publisher
Wiley
Citation
Cao, Yunteng, Koh, Sally Shuxian, Han, Yangyang, Tan, Javier Jingheng, Kim, Doyoon et al. 2023. "Drug Delivery in Plants Using Silk Microneedles." Advanced Materials, 35 (2).
Version
Final published version
Abstract
New systems for agrochemical delivery in plants will foster precise agricultural practices and provide new tools to study plants and design crop traits, as standard spray methods suffer from elevated loss and limited access to remote plant tissues. Silk-based microneedles can circumvent these limitations by deploying a known amount of payloads directly in plants' deep tissues. However, plant response to microneedles' application and microneedles' efficacy in deploying physiologically relevant biomolecules are unknown. Here, it is shown that gene expression associated with Arabidopsis thaliana wounding response decreases within 24 h post microneedles' application. Additionally, microinjection of gibberellic acid (GA3 ) in A. thaliana mutant ft-10 provides a more effective and efficient mean than spray to activate GA3 pathways, accelerating bolting and inhibiting flower formation. Microneedle efficacy in delivering GA3 is also observed in several monocot and dicot crop species, i.e., tomato (Solanum lycopersicum), lettuce (Lactuca sativa), spinach (Spinacia oleracea), rice (Oryza Sativa), maize (Zea mays), barley (Hordeum vulgare), and soybean (Glycine max). The wide range of plants that can be successfully targeted with microinjectors opens the doors to their use in plant science and agriculture.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adma.202205794
