Enhancing the injectability of high concentration drugs via core annular flows
Name
1201697608-MIT.pdf
Size
3.99 MB
Format
Adobe PDF
Checksum (MD5)
636f06bcebd6967378e654c8e7d98762
Author(s)
Jayaprakash, Vishnu.
Advisor(s)
Kripa K. Varanasi.
Date Issued
2019
Publisher
Massachusetts Institute of Technology
Abstract
High concentration drug formulations that can be delivered via subcutaneous injections offer tremendous benefits to global health, but their high viscosity prevents injectability through medical needles. Current approaches to solve this problem face several challenges ranging from cross contamination and high cost to needle clogging and protein inactivation. Here we report a simple method to enhance formulation injectability through a core annular flow that lubricates viscous transport through a needle. We study the importance of different flow regimes and density based eccentricity in dictating lubrication in the needle. Finally, we quantify the maximum pressure reduction that can be achieved with such a lubricating core annular flow.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, June, 2019
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 31-32).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.
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