SARS-CoV-2 Quantum Sensor Based on Nitrogen-Vacancy Centers in Diamond
Name
nl1c02868.pdf
Description
Accepted version
Size
2.31 MB
Format
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Checksum (MD5)
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Author(s)
Li, Changhao
Soleyman, Rouhollah
Kohandel, Mohammad
Cappellaro, Paola
Date Issued
2022
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Li, Changhao, Soleyman, Rouhollah, Kohandel, Mohammad and Cappellaro, Paola. 2022. "SARS-CoV-2 Quantum Sensor Based on Nitrogen-Vacancy Centers in Diamond." Nano Letters, 22 (1).
Version
Author's final manuscript
Abstract
The development of highly sensitive and rapid biosensing tools targeted to
the highly contagious virus SARS-CoV-2 is critical to tackling the COVID-19
pandemic. Quantum sensors can play an important role, thanks to their superior
sensitivity and fast improvements in recent years. Here we propose a molecular
transducer designed for nitrogen-vacancy (NV) centers in nanodiamonds,
translating the presence of SARS-CoV-2 RNA into an unambiguous magnetic noise
signal that can be optically read out. We evaluate the performance of the
hybrid sensor, including its sensitivity and false negative rate, and compare
it to widespread diagnostic methods. The proposed method is fast and promises
to reach a sensitivity down to a few hundreds of RNA copies with false negative
rate less than 1%. The proposed hybrid sensor can be further implemented with
different solid-state defects and substrates, generalized to diagnose other RNA
viruses, and integrated with CRISPR technology.
MIT Department
Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1021/ACS.NANOLETT.1C02868
