Localized microstimulation of primate pregenual cingulate cortex induces negative decision-making
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Graybiel_Localized microstimulation.pdf
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4.47 MB
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Author(s)
Amemori, Ken-ichi
Graybiel, Ann M.
Date Issued
April 2012
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Amemori, Ken-ichi, and Ann M Graybiel. “Localized Microstimulation of Primate Pregenual Cingulate Cortex Induces Negative Decision-Making.” Nat Neurosci 15, no. 5 (April 8, 2012): 776–785.
Version
Author's final manuscript
Abstract
The pregenual anterior cingulate cortex (pACC) has been implicated in human anxiety disorders and depression, but the circuit-level mechanisms underlying these disorders are unclear. In healthy individuals, the pACC is involved in cost-benefit evaluation. We developed a macaque version of an approach-avoidance decision task used to evaluate anxiety and depression in humans and, with multi-electrode recording and cortical microstimulation, we probed pACC function as monkeys performed this task. We found that the macaque pACC has an opponent process-like organization of neurons representing motivationally positive and negative subjective value. Spatial distribution of these two neuronal populations overlapped in the pACC, except in one subzone, where neurons with negative coding were more numerous. Notably, microstimulation in this subzone, but not elsewhere in the pACC, increased negative decision-making, and this negative biasing was blocked by anti-anxiety drug treatment. This cortical zone could be critical for regulating negative emotional valence and anxiety in decision-making.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/nn.3088
