Building Robust Transcriptomes with Master Splicing Factors
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Sharp_Building robust.pdf
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Author(s)
Sharp, Phillip A.
Jangi, Mohini Rohit
Date Issued
October 2014
Journal
Cell
Publisher
Elsevier
Citation
Jangi, Mohini, and Phillip A. Sharp. “Building Robust Transcriptomes with Master Splicing Factors.” Cell 159, no. 3 (October 2014): 487–498. © 2014 Elsevier Inc.
Version
Author's final manuscript
Abstract
Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or “master splicing factors,” respond to environmental cues to establish and maintain tissue transcriptomes during development.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.cell.2014.09.054
