An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets
Name
1-s2.0-S2211124720314224-main.pdf
Description
Published version
Size
4.18 MB
Format
Adobe PDF
Checksum (MD5)
98fa71cd49297f2ac3cf387283146c17
Author(s)
Zhang, Huiyuan
Madi, Asaf
Yosef, Nir
Chihara, Norio
Awasthi, Amit
Pot, Caroline
Lambden, Conner
Srivastava, Amitabh
Burkett, Patrick R
Nyman, Jackson
Date Issued
2020
Journal
Cell Reports
Publisher
Elsevier BV
Version
Final published version
Abstract
Zhang et al. construct a transcriptional network for IL-27-mediated Il10 production in CD4 T cells, characterize the function of 16 Il10 regulators, and uncover the role of two transcription factors, Prdm1 and Maf, in driving Il10 production in all T helper cells and in maintaining immune homeostasis in the colon.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Howard Hughes Medical Institute
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.celrep.2020.108433
