Hippocampal regulation of aversive memories
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Goosens_Hippocampal regulation.pdf
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677.87 KB
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173d312ff0a50a23eded20bf7a65b188
Author(s)
Goosens, Ki Ann
Date Issued
May 2011
Journal
Current Opinion in Neurobiology
Publisher
Elsevier
Citation
Goosens, Ki Ann. “Hippocampal Regulation of Aversive Memories.” Current Opinion in Neurobiology 21, no. 3 (June 2011): 460–466.
Version
Author's final manuscript
Abstract
For many years, the hippocampal formation has been implicated in the regulation of negative emotion, yet the nature of this link has remained elusive. Recent studies have made important links between the hippocampus and regulation of stress hormones that affect aversive memory. Additional studies have shown that the hippocampus regulates the gating of fear by contextual information. An emerging literature also links the hippocampus to prediction errors during fear learning and extinction. The mechanisms by which the hippocampus regulates negative emotion are clearly complicated, but suggest that interventions aimed at restoring normal hippocampal function may help with disorders of negative affect, such as depression or post-traumatic stress disorder and depression.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.conb.2011.04.003
