Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage
Name
Olsen_Shear-thinning.pdf
Size
7.17 MB
Format
Adobe PDF
Checksum (MD5)
8de54db3c62d03ed2b889ef598ccc2bb
Name
correction-to-shear-thinning-nanocomposite-hydrogels-for-the-treatment-of-hemorrhage.pdf
Description
Correction
Size
2.66 MB
Format
Adobe PDF
Checksum (MD5)
e8adc26f06cb0d246784b38d044acd26
Author(s)
Assmann, Alexander
Paul, Arghya
Khademhosseini, Ali
Avery, Reginald Keith
Gaharwar, Akhilesh
McKinley, Gareth H
Olsen, Bradley D
Date Issued
September 2014
Journal
ACS Nano
Publisher
American Chemical Society (ACS)
Citation
Gaharwar, Akhilesh K., Reginald K. Avery, Alexander Assmann, Arghya Paul, Gareth H. McKinley, Ali Khademhosseini, and Bradley D. Olsen. “Shear-Thinning Nanocomposite Hydrogels for the Treatment of Hemorrhage.” ACS Nano 8, no. 10 (October 28, 2014): 9833–42. © 2014 American Chemical Society
Version
Final published version
Abstract
Internal hemorrhaging is a leading cause of death after traumatic injury on the battlefield. Although several surgical approaches such as the use of fibrin glue and tissue adhesive have been commercialized to achieve hemostasis, these approaches are difficult to employ on the battlefield and cannot be used for incompressible wounds. Here, we present shear-thinning nanocomposite hydrogels composed of synthetic silicate nanoplatelets and gelatin as injectable hemostatic agents. These materials are demonstrated to decrease in vitro blood clotting times by 77%, and to form stable clot-gel systems. In vivo tests indicated that the nanocomposites are biocompatible and capable of promoting hemostasis in an otherwise lethal liver laceration. The combination of injectability, rapid mechanical recovery, physiological stability, and the ability to promote coagulation result in a hemostat for treating incompressible wounds in out-of-hospital, emergency conditions.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/nn503719n
