Assessment of Artifacts and Reproducibility across Spectral- and Time-Domain Optical Coherence Tomography Devices
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Fijimoto_Assessment of Artifacts.pdf
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Author(s)
Ho, Joseph
Sull, Alan C.
Vuong, Laurel N.
Chen, Yueli
Fujimoto, James G.
Schuman, Joel S.
Duker, Jay S.
Liu, Jonathan Jaoshin
Date Issued
July 2009
Journal
Ophthalmology
Publisher
Elsevier
Citation
Ho, Joseph, Alan C. Sull, Laurel N. Vuong, Yueli Chen, Jonathan Liu, James G. Fujimoto, Joel S. Schuman, and Jay S. Duker. “Assessment of Artifacts and Reproducibility Across Spectral- and Time-Domain Optical Coherence Tomography Devices.” Ophthalmology 116, no. 10 (October 2009): 1960–1970.
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Author's final manuscript
Abstract
Purpose
To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device.
Design
Prospective, noncomparative, noninterventional case series.
Participants
Fifty-two patients seen at the New England Eye Center, Tufts Medical Center Retina Service, between February and August 2008.
Methods
Two scans were performed for each of the SD OCT protocols: Cirrus macular cube 512×128 (software version 3.0; Carl Zeiss Meditec, Inc., Dublin, CA), RTVue (E)MM5 and MM6 (software version 3.5; Optovue, Inc., Fremont, CA), Topcon 3D Macular and Radial (software version 2.12; Topcon, Inc., Paramus, NJ), in addition to 1 TD OCT scan via Stratus macular thickness protocol (software version 4.0; Carl Zeiss Meditec, Inc.). Scans were inspected for 6 types of OCT scan artifacts and were analyzed. Interscan reproducibility and interdevice agreeability were assessed by intraclass correlation coefficients (ICCs) and Bland-Altman plots, respectively.
Main Outcome Measures
Optical coherence tomography image artifacts, macular thickness, reproducibility, and agreeability.
Results
Time-domain OCT scans contained a significantly higher percentage of clinically significant improper central foveal thickness (IFT) after manual correction (11-μm change or more) compared with SD OCT scans. Cirrus HD-OCT had a significantly lower percentage of clinically significant IFT (11.1%) compared with the other SD OCT devices (Topcon 3D, 20.4%; Topcon Radial, 29.6%; RTVue (E)MM5, 42.6%; RTVue MM6, 24.1%; P = 0.001). All 3 SD OCT devices had central foveal subfield thicknesses that were significantly more than that of TD OCT after manual correction (P<0.0001). All 3 SD OCT devices demonstrated a high degree of reproducibility in the central foveal region (ICCs, 0.92–0.97). Bland-Altman plots showed low agreeability between TD and SD OCT scans.
Conclusions
Out of all OCT devices analyzed, cirrus HD-OCT scans exhibited the lowest occurrence of any artifacts (68.5%), IFT (40.7%), and clinically significant IFT (11.1%), whereas Stratus OCT scans exhibited the highest occurrence of clinically significant IFT. Further work on improving segmentation algorithm to decrease artifacts is warranted.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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DOI of Published Version
https://doi.org/10.1016/j.ophtha.2009.03.034
