Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures
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Author(s)
de Carvalho, Jancineide Oliveira
de Carvalho Oliveira, Francilio
Freitas, Sérgio Antonio Pereira
Soares, Liana Martha
de Cássia Barros Lima, Rita
de Sousa Gonçalves, Licia
Webster, Thomas Jay
Marciano, Fernanda Roberta
Lobo, Anderson Oliveira
Date Issued
September 2018
Journal
Current Osteoporosis Reports
Publisher
Springer Science and Business Media LLC
Citation
de Carvalho, Jancineide Oliveira et al. "Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures." Current Osteoporosis Reports 16, 5 (September 2018): 626–634. © 2018 Springer Science Business Media
Version
Author's final manuscript
Abstract
Purpose of Review: To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). Recent Findings: The results show that the physical and chemical properties of the nanomaterials are suitable for the fabrication of scaffolds intended for bone regeneration. The in vitro tests suggested a non-toxicity of the GNRs as well as improved biocompatibility and bone mineralization activity. Summary: Here, for the first time, we evaluated the potential of GNRs in remodeling and repairing bone defects in osteoporotic animal models in vivo. Interestingly, bone mineralization and the initiation of the remodeling cycle by osteoclasts/osteoblasts were observed after the implantation of GNRs, thus implying healthy bone remodeling when using GNRs. This study, therefore, has opened our perspectives and certainly calls for more attention to the use of carbon nanomaterials for a wide range of osteoporosis applications.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s11914-018-0476-2
