Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1
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Bear_Visual recognition.pdf
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Author(s)
Cooke, Samuel Frazer
Komorowski, Robert
Kaplan, Eitan S.
Gavornik, Jeffrey
Bear, Mark
Date Issued
January 2015
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Cooke, Sam F, Robert W Komorowski, Eitan S Kaplan, Jeffrey P Gavornik, and Mark F Bear. “Visual Recognition Memory, Manifested as Long-Term Habituation, Requires Synaptic Plasticity in V1.” Nat Neurosci 18, no. 2 (January 19, 2015): 262–271.
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Author's final manuscript
Abstract
Familiarity with stimuli that bring neither reward nor punishment, manifested through behavioral habituation, enables organisms to detect novelty and devote cognition to important elements of the environment. Here we describe in mice a form of long-term behavioral habituation to visual grating stimuli that is selective for stimulus orientation. Orientation-selective habituation (OSH) can be observed both in exploratory behavior in an open arena and in a stereotyped motor response to visual stimuli in head-restrained mice. We found that the latter behavioral response, termed a 'vidget', requires V1. Parallel electrophysiological recordings in V1 revealed that plasticity, in the form of stimulus-selective response potentiation (SRP), occurred in layer 4 of V1 as OSH developed. Local manipulations of V1 that prevented and reversed electrophysiological modifications likewise prevented and reversed memory demonstrated behaviorally. These findings suggest that a form of long-term visual recognition memory is stored via synaptic plasticity in primary sensory cortex.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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DOI of Published Version
https://doi.org/10.1038/nn.3920
