Biomolecular Condensates in the Nucleus
Name
nihms-1607384.pdf
Description
Accepted version
Size
2.31 MB
Format
Adobe PDF
Checksum (MD5)
b09521f7636e74295fe327a96bc7e0f4
Author(s)
Sabari, Benjamin R
Dall’Agnese, Alessandra
Young, Richard A
Date Issued
2020
Journal
Trends in Biochemical Sciences
Publisher
Elsevier BV
Citation
Sabari, Benjamin R, Dall’Agnese, Alessandra and Young, Richard A. 2020. "Biomolecular Condensates in the Nucleus." Trends in Biochemical Sciences, 45 (11).
Version
Author's final manuscript
Abstract
© 2020 Elsevier Ltd Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their way to specific locations has been assumed to occur largely by diffusion-mediated collisions. Recent studies have shown that many nuclear processes occur within condensates that compartmentalize and concentrate the protein and RNA molecules required for each process, typically at specific genomic loci. These condensates have common features and emergent properties that provide the cell with regulatory capabilities beyond canonical molecular regulatory mechanisms. We describe here the shared features of nuclear condensates, the components that produce locus-specific condensates, elements of specificity, and the emerging understanding of mechanisms regulating these compartments.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.TIBS.2020.06.007
