Mapping the Spatial Transcriptome Across Whole Organisms
Name
zhang-ruihanz-PhD-MAS-2025-thesis.pdf
Description
Thesis PDF
Size
74.34 MB
Format
Adobe PDF
Checksum (MD5)
06ddb8f995c3d530d8d86acf6bf28c89
Author(s)
Zhang, Ruihan
Advisor(s)
Jacobson, Joseph M.
Boyden, Edward S.
Date Issued
February 2025
Publisher
Massachusetts Institute of Technology
Abstract
This study utilizes Expansion Sequencing (ExSeq) to thoroughly investigate the spatial transcriptome of the Caenorhabditis elegans (C. elegans) body. Beyond mapping gene distribution within individual specimens, this research sequences multiple C. elegans to identify both shared and distinct transcriptomic features. The findings lay crucial groundwork for future integration of transcriptomic data with in situ connectomics and in vivo neural activity recordings. Understanding the spatial transcriptome in C. elegans is vital for insights into neural circuit coordination, disease mechanisms, and developmental biology.
MIT Department
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Terms of Use
In Copyright - Educational Use Permitted
Copyright retained by author(s)
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