Evolution towards Virulence in a Burkholderia Two-Component System
Name
mBio.01823-21.pdf
Description
Published version
Size
2.64 MB
Format
Adobe PDF
Checksum (MD5)
be20e50c7df923134e57e485c60db877
Author(s)
Schaefers, Matthew M
Wang, Benjamin X
Boisvert, Nicole M
Martini, Sarah J
Bonney, Sarah L
Marshall, Christopher W
Laub, Michael T
Cooper, Vaughn S
Priebe, Gregory P
Date Issued
2021
Journal
mBio
Publisher
American Society for Microbiology
Citation
Schaefers, Matthew M, Wang, Benjamin X, Boisvert, Nicole M, Martini, Sarah J, Bonney, Sarah L et al. 2021. "Evolution towards Virulence in a Burkholderia Two-Component System." mBio, 12 (4).
Version
Final published version
Abstract
Infections caused by members of the Burkholderia cepacia complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are often resistant to many antibiotics. During long-term infection of CF patients with BCC, mutations in genes encoding the FixLJ system often become prevalent, suggesting that these changes may benefit the bacteria during infection.
Infections caused by members of the Burkholderia cepacia complex (BCC) are a serious concern for patients with cystic fibrosis (CF) as these bacteria are often resistant to many antibiotics. During long-term infection of CF patients with BCC, mutations in genes encoding the FixLJ system often become prevalent, suggesting that these changes may benefit the bacteria during infection.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1128/MBIO.01823-21
