An emerging role of mTOR in lipid biosynthesis
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Sabatini_An emerging.pdf
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1.87 MB
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Adobe PDF
Checksum (MD5)
670ad7cc5d6045a785afba01b7ffe0e7
Author(s)
Laplante, Mathieu
Sabatini, David
Date Issued
December 2009
Journal
Current Biology
Publisher
Elsevier Ltd.
Citation
Laplante, Mathieu, and David M. Sabatini. “An Emerging Role of mTOR in Lipid Biosynthesis.” Current Biology 19.22 (2009): R1046–R1052.
Version
Author's final manuscript
Abstract
Lipid biosynthesis is essential for the maintenance of cellular homeostasis. The lipids produced by cells (glycerolipids, fatty acids, phospholipids, cholesterol, and sphingolipids) are used as an energy source/reserve, as building blocks for membrane biosynthesis, as precursor molecules for the synthesis of various cellular products, and as signaling molecules. Defects in lipid synthesis or processing contribute to the development of many diseases, including obesity, insulin resistance, type 2 diabetes, non-alcoholic fatty liver disease, and cancer. Studies published over the last few years have shown that the target of rapamycin (TOR), a conserved serine/threonine kinase with an important role in regulating cell growth, controls lipid biosynthesis through various mechanisms. Here, we review these findings and briefly discuss their potential relevance for human health and disease.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.cub.2009.09.058
