Combinatorial discovery of polymers resistant to bacterial attachment
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Anderson_Combinatorial discovery.pdf
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Author(s)
Hook, Andrew L.
Chang, Chien-Yi
Yang, Jing
Luckett, Jeni
Cockayne, Alan
Atkinson, Steve
Mei, Ying
Bayston, Roger
Irvine, Derek J.
Williams, Paul
Date Issued
August 2012
Journal
Nature Biotechnology
Publisher
Nature Publishing Group
Citation
Hook, Andrew L, Chien-Yi Chang, Jing Yang, Jeni Luckett, Alan Cockayne, Steve Atkinson, Ying Mei, et al. “Combinatorial Discovery of Polymers Resistant to Bacterial Attachment.” Nature Biotechnology 30, no. 9 (August 12, 2012): 868–875.
Version
Author's final manuscript
Abstract
Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput microarray format. Using this method, we identified a group of structurally related materials comprising ester and cyclic hydrocarbon moieties that substantially reduced the attachment of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli). Coating silicone with these 'hit' materials achieved up to a 30-fold (96.7%) reduction in the surface area covered by bacteria compared with a commercial silver hydrogel coating in vitro, and the same material coatings were effective at reducing bacterial attachment in vivo in a mouse implant infection model. These polymers represent a class of materials that reduce the attachment of bacteria that could not have been predicted to have this property from the current understanding of bacteria-surface interactions.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/nbt.2316
